1. That's why I shared it. It's not true that they can only use fat.

  2. Thank you. Maybe it was something that showed the heart prefers fat as a source, or primarily uses fat.

  3. I thought proteins were the building blocks of cells. (not disagreeing with you I just didn't know that fat was both a fuel and a building block).

  4. Both proteins and fats are used throughout our cells as building material. Our cell walls in particular are made of fats.

  5. My suspicion is that people at higher altitudes are also getting stronger doses of infrared radiation, increasing their mitochondrial melatonin, which protects against mitochondrial damage.

  6. lately I’ve been really appreciating the simplicity of sashimi and nagiri. What I do want to know is… what’s the verdict on soy sauce? Not sure where it stands with this subreddit, but I try to avoid soy when I can. Soy sauce has been an exception though because I like it with sushi

  7. Soy sauce should be fine. It has essentially no fat, which means no PUFA. I like to use real fermented soy sauce.

  8. He's doing great! Just got the all-clear at his latest cardiology visit.

  9. This is interesting. Has your dad had other periods of normal in the recent past or has it been quite a while?

  10. This is the first time he’s ever seen an improvement. I think he wants to stick with this for a while and see where it goes.

  11. Check the fats and oils section of the Omega-6 food guide, they're all there:

  12. A high SFA diet increases the burning of body fat, especially at night when fasting. This can increase your release of PUFA including in the form of oxLDL. I recommend boosting your innate antioxidant defenses with red light therapy.

  13. Any info on how being out in direct, hot sun compares with red light therapy?

  14. Direct sunlight will also give you UV radiation which is a source of oxidative stress. You need indirect sunlight to get infrared without UV.

  15. I don't know how sunlight compares. PBM is obviously much more concentrated compared the sunlight, especially for the specifically healing frequencies of red light. If you can find any information about that I'd really appreciate it. Presumably there is a lot of variation in terms of altitude and latitude, as well as the effects of time of day and air pollution.

  16. MUFA should definitely be less oxidative than PUFA. In a PUFA free world, would MUFA alone be enough to trigger torpor? I thought Brad said no to that?

  17. Glycolysis is the breakdown of glucose to acetyl groups. Beta oxidation is the breakdown of fats to acetyl groups. The citric acid cycle is the breakdown of acetyl groups to create a proton (hydrogen ion) gradient via the electron transport chain. Oxidative phosphorylation is the final step of energy creation, which uses the proton gradient to do work (store chemical energy in ATP).

  18. Ahh, beta oxidation, that's what I was forgetting. I got it confused with the oxidative phosphorylation. And beta oxidation is part of the citric acid cycle, right?

  19. What’s the recommended regimen to heal a damaged metabolism?

  20. Low carb, low omega-6, high saturated fat. Use red light therapy, especially at night, to boost your mitochondrial melatonin. Your body will do the rest.

  21. Is there a test to determine extent of damage and/or measure progress?

  22. You can track your chronic inflammation status with blood tests like the Vectra test. Blood sugar management is another indicator. You should expect systematic health improvements within weeks or months. There’s no way to directly measure mitochondria at this time.

  23. Unfortunately most chickens raised on pasture are still fed soy and corn. That includes fancy brands like Vital Farms. They do have slightly better fat profiles than conventional eggs but not by a lot. Soy free eggs are available in a few places which should be a bit better since soy is the worst for omega-6. Genuinely low PUFA eggs are very hard to get, Angel Acres is my source and they’re not cheap. Unfortunately you really might have to just limit yourself to 2 eggs a day at most.

  24. Couple points here to address: The PUFA may have been slowing your metabolism (that's what they do to induce hibernation) so that while you sleep, no harm is done because the innate antioxidants were easily to suppress any "fat burning" detriments. Once you switched to SFA, the metabolism ramps up which also means the antioxidants can no longer keep up. Basically the training wheels are off so to speak... which is both good and bad.

  25. Unfortunately, PUFA slow our metabolisms by literally breaking our mitochondria, generating lots of oxidative stress in the process. So I seriously doubt the PUFA were acting protectively here. I do agree that with SFA the training wheels are off, because SFA seems to have a separate effect.

  26. This is a sweet take. I’m this day old with that pufa concern- I’m guessing it’s the reason I have stubborn trunk accumulation- I didn’t steer clear of pufas in high school.

  27. I'm seeing multiple posts here asking "would X work instead of light therapy?" I think you're getting those questions because it's not clear to people what is unique about IR light VS heat or looking at a picture of a sunset. I'm going to try to explain in an accessible manner what the unique thing that IR light is providing that other sources of heat/energy would not:

  28. Wish some of this was affordable in the third world. I alternate between low/no pufa eating ad libitum and fasting as long as I can (3 days on average). I have no way of telling my oxidative stress in particular but anecdotally, having lost 20 of the 30kg I want in order to return to a lean and healthy body composition, each round of fasting feels easier and each subsequent round of eating rebounds a little less.

  29. If you can't afford red light therapy, you should try to get as much infrared sunlight as possible. Avoid direct UV, a source of oxidative stress.The first and last hour of sunlight is rich in infrared and low in UV. Being outside and out of direct sun, but around nature and green plants will reflect infrared onto you from all directions.

  30. Perhaps the frequency matters? I can believe that taking antiox supplements every day could downrate internal antioxidant systems, resulting in worse health. But maybe taking them once a week could relieve some ox stress without downrating the internal systems? Seems like there are possible analogies here with exercise every day vs twice a week, occasional ice baths, etc. And the whole hormesis thing of course, do we want more or less to make the body healthier? (I think some people have suggested that vegetables actually improve health via harm?!)

  31. I think the essential problem is that antioxidants need to be in the mitochondria where the damage is happening. Supplements don’t do that. That leaves a bunch of reductive stress on the rest of the body.

  32. This may be apropos of nothing, but when I have a head cold I get extremely emotionally depressed. Now, I know in a rational sense there is no reason for me to be depressed in such a severe way. I also know from experience that this is a side effect of the head cold. So I assume that the inflammation associated with the head cold has caused the depression. I just find this an interesting phenomenon to observe in myself. The depression actually comes on one day before the onset of head cold. Sometimes, but not always- I realize the depression is a harbinger of coming illness. Other times I think -why the hell am I so depressed all of a sudden?

  33. Because when you’re sick, you have a higher oxidative load. This puts a strain on your antioxidant systems, and serotonin is converted to melatonin and used up. Result: depression.

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