High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study.

Schoenen J, et al.

Forty-nine individuals with recurrent migraines were given riboflavin, 400 mg/day with breakfast, for at least 3 months. The mean number of migraine attacks fell by 67% and mean migraine severity improved by 68%. One patient stopped treatment because of gastric intolerance (that person was also taking small amounts of aspirin), but no other side effects occurred.

Cephalalgia 1994;14:328-329

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