We found significantly increased HNE levels in female migraineurs compared with controls. Logistic regression analyses of HNE revealed an odds ratio for migraine of 4.55. HNE showed significant correlations with the nitric oxide pathway, the insulin- and the lipid-metabolism.

  1. HNE damaging the Nitric Oxide pathway is interesting, since a lack of NO causes endothelium dsyfunction. This ties in with what Dr Twyman and Dr Saladino discussed regarding atherosclerosis.

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